Check Closely (1)istradefylline will raise the amount or result of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism.fluvoxamine will raise the degree or effect of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.topiramate will decrease the extent or influence of diazepam by impacting